Captopril

Usual solid dosage form
Tablets
Available as a liquid
Yes
Available as a licensed liquid formulation?
Yes - oral solution
Liquid strengths
5mg/5mL, 25mg/5mL
Liquid sugar free or not
Yes
Additional information for Healthcare Professionals+
Dissolve directly in mouth
No
Available as soluble tablets
No
Sub-lingual
No
Specially coated?
No
Available as an unlicensed special liquid formulation?
Yes - oral suspension, oral solution
Licensed for administration via enteral tube
No
Advice on administration via enteral tube
Current resources suggest that it is likely to be safe to administer crushed tablets via enteral feeding tubes. Stop the enteral feed before administration. Crush the tablet and mix with 15-30mL of water. Draw up the solution into a 50mL enteral syringe then administer via enteral feeding tube. Flush the feeding tube with water before and after administration of the medication. No break in feeding is required after the medication has been administered (see note).
Available as other formulations?
No
Note
Absorption of captopril can be reduced if given at the same time as food or milk. Consider withholding enteral feed for 30 minutes before and after each dose if clinical effect is insufficient.
Film coated
No
Modified release
No
Enteric coated
No
Sugar coated
No
Generic drug
Captopril
Safe or appropriate to crush
Licensed alternative formulations available and therefore crushing is not recommended. Crushing or dispersing should always be used as a last resort but current text books and resources suggest it is likely to be safe to crush tablets and disperse in water immediately prior to administration. Clinicians should be aware that this is an unlicensed use of the medication.