Cyclizine

Usual solid dosage form
Tablets
Available as a liquid
No
Available as a licensed liquid formulation?
No
Liquid strengths
n/a
Liquid sugar free or not
n/a
Additional information for Healthcare Professionals+
Dissolve directly in mouth
No
Available as soluble tablets
No
Sub-lingual
No
Specially coated?
No
Available as an unlicensed special liquid formulation?
Yes- oral suspension, oral solution
Licensed for administration via enteral tube
No
Advice on administration via enteral tube
Consider administering as the parenteral injection if appropriate or changing patient to an alternative anti-emetic for which liquid/suppositories are available (e.g. domperidone/metoclopramide). If neither option is suitable then current resources suggest that it is likely to be safe to crush tablets and administer via enteral feeding tubes. Stop the enteral feed before administration. Crush tablets, add 15-30mL of water and mix well. Draw up mixture with a 50mL enteral syringe and administer via enteral feeding tube. Flush the feeding tube with water before and after administration of the medication. No break in feeding is required after the medication has been administered.
Available as other formulations?
Injection (50mg/mL)
Note
Tablets are poorly soluble in water and will need shaking for 5 minutes and administering immediately.
Film coated
No
Modified release
No
Enteric coated
No
Sugar coated
No
Generic drug
Cyclizine
Safe or appropriate to crush
Crushing or dispersing should always be used as a last resort but current text books and resources suggest it is likely to be safe. Clinicians should be aware that this is an unlicensed use of the medication. Consider changing to an alternative medication for which other formulations are available.