Topiramate

Usual solid dosage form
Tablet
Available as a liquid
Yes
Available as a licensed liquid formulation?
Yes- oral suspension
Liquid strengths
50mg/5mL, 100mg/5mL
Liquid sugar free or not
Yes. Safe for people with diabetes.
Additional information for Healthcare Professionals+
Dissolve directly in mouth
No
Available as soluble tablets
No
Sub-lingual
No
Specially coated?
Yes
Available as an unlicensed special liquid formulation?
Yes- oral suspension
Licensed for administration via enteral tube
No
Advice on administration via enteral tube
Current resources suggest that it is likely to be safe to administer crushed tablets via enteral feeding tubes. Stop the enteral feed before administration. Crush the tablet and mix with 15-30mL of water. Draw up the solution into a 50mL enteral syringe then administer via enteral feeding tube. Flush the feeding tube with water before and after administration of the medication. No break in feeding is required after the medication has been administered. It is not generally recommended to administer the contents of sprinkle capsules via enteral feeding tubes. If this is required then a large-bore tube must be used and the tube must be well flushed after administration as the capsule contents may adhere to the sides of the tube and cause blockage.
Available as other formulations?
Sprinkle capsule
Note
The clinical effectiveness of topiramate may be reduced if administered via tubes which terminate in the jejunum. There may be variability between brands of topiramate, so every effort should be made to maintain the patient on the same brand if the medication is being used for seizure control. Where changes in brand or formulation are unavoidable the patient must be closely monitored.
Film coated
Yes
Modified release
No
Enteric coated
No
Sugar coated
No
Generic drug
Topiramate
Safe or appropriate to crush
Licensed alternative formulations available and therefore crushing is not recommended. Crushing or dispersing should always be used as a last resort but current text books and resources suggest that crushing Topamax brand tablets is likely to be safe. Clinicians should be aware that this an unlicensed use of the medication.